Spaces are bold and brash the crimson-hued lobby bar features golden trees, while Wazuzu restaurant, also cloaked in red, features a shimmering Swarovski crystal-studded dragon on one of its walls and an eye-catching pattern of fans lining the carpet. Opulent interiors drip with excess, such as the lobby area sprouting trees from colorful flowerbeds, some dotted with peacock-shaped lighting fixtures with illuminated plumes of feathers. Much of the hotel, including its casino and pools, feels like a carbon copy to the Wynn, but that isn't a bad thing. Encore, however, feels a tad quieter and less hectic than the Wynn - except for the Encore Beach Club, which draws hundreds of people on a daily basis. Opened in December 2008 by famed Las Vegas developer Steve Wynn, the 2,034-room Encore At Wynn Las Vegas takes the whim and luxury of its next-door sister, the Wynn Las Vegas (opened in 2005), and steps it up a notch with even bigger rooms and a more attractive spa and fitness center. The Italian-inspired Venetian is a family-friendly alternative with lower rates, gondola rides, and faster access to the southern end of the Strip. ![]() It all comes at a price though - rates are high, as are food and drink at any of the venues, plus there are daily resort fees added (typical for Vegas). There are a luxe casino and adjacent golf course as well. Two nightclubs regularly host top DJs, while shows at the Encore Theater are also popular. The giant suites are some of the biggest on the Strip (starting at 745 square feet!) and one-up even the Wynn's (Encore's next-door sister), plus they're decked out with modern amenities and luxurious marble bathrooms with soaking tubs and separate showers. View more Amex offers here & if you have any questions abut American Express offers then read this post.Opened in December 2008, the 2,034-room Encore At Wynn Las Vegas is a luxury property on The Strip that’s all about pure opulence, from its impressive interiors to its decadent spa to the array of restaurants, gaming tables, and several attractive pools - including a European-style pool with topless sunbathing. If your stay is going to be after the end date then you should be able to call up and pay in advance and it will still trigger the offer. Excludes La Cave, Cipriani, Urth Caffé, XS Nightclub, Encore Beach Club, Encore Beach Club Nightswim, Intrigue Nightclub, and Encore Players Lounge. Excludes purchases for Air & Hotel Packages, Master Classes, Show Experiences, Sports Experiences, theaters, catering, parking, and all other amenities. Excludes all retail, casino, and gambling related purchases. ![]()
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Since most people are first timers they probably run into the same issues as me thinking that the main floor has great views but then find it to be less than ideal. Auditoria can be found in entertainment venues, community halls, and theaters, and may be used for rehearsal, presentation. For movie theatres, the number of auditoria (or auditoriums) is expressed as the number of screens. This was my first time at the Ryman Auditorium and I didn't realize how different the views could be in such a small venue. An auditorium is a room built to enable an audience to hear and watch performances.
In June, Brown chaired a hearing with Chair Powell and urged him to prioritize working families in the face of rising consumer prices.Ī copy of the letter is available here and below:Īs you know, the Federal Reserve is charged with the dual mandate of promoting maximum employment, stable prices, and moderate long-term interest rates in the U.S. ![]() In July, he released a statement on the FOMC’s rate hike and urged action on corporate price gouging and consolidation to ease consumer costs. I ask that you don’t forget your responsibility to promote maximum employment and that the decisions you make at the next FOMC meeting reflect your commitment to the dual mandate.”īrown has long fought to protect Americans’ pocketbooks against inflation. We can’t risk the livelihoods of millions of Americans who can’t afford it. “For working Americans who already feel the crush of inflation, job losses will make it much worse. “As you know, the Federal Reserve is charged with the dual mandate of promoting maximum employment, stable prices, and moderate long-term interest rates in the U.S. The letter makes clear that the Fed’s fight against inflation must not hurt workers. Sherrod Brown (D-OH), Chair of the Senate Committee on Banking, Housing, and Urban Affairs, sent a letter to Jerome Powell, Chair of the Board of Governors of the Federal Reserve, to remind the Federal Reserve of its responsibility to maintain full employment. ![]() ![]() OctoAhead of FOMC Meeting, Brown Reminds Chair Powell of the Fed's Mandate to Promote Maximum Employment ‘Autumn Blaze’ is a new hybrid cross between a red and silver maple with fast growth rate, brilliant fall color and good drought tolerance.Įxcerpted from my book, New England Getting Started Garden Guide. ‘Silver Queen’ is a good silver maple selection. ‘Cinnamon Flake’ is a newer paperbark maple hybrid that’s hardy to zone 5. ‘Green Mountain’ is a good sugar maple selection. ‘Armstrong’, ‘October Glory’ and ‘Red Sunset’ are some of the red maples with particularly good fall foliage color. Avoid planting invasive maples, such as ‘Norway maple ( A. Additionally, use well-draining potting soil and provide the tree with enough sunlight and water to. For a more ornamental tree, try the paperbark maple for its shorter stature (30 feet tall) and exfoliating cinnamon-brown bark. so its best to choose a pot at least 2 feet deep and wide. Their shallow roots with buckle pavement. But don’t plant silver maples near a sidewalk or driveway. In wet areas near ponds or streams, select silver maples. Neither condition is a concern.įor shade trees, grow red maples ( A. Trees may get black tar spot blotches on their leaves during wet summers or leaf scorch during hot, dry conditions. Silver maples have weak wood that often breaks in storms. Remove dead, diseased and broken limbs as needed. Plant Type: Dormant, bare-root Zones: 3-8 Soil Type: Loamy & Sandy Soils Site Selection: Full Sun, Partial Sun, Shade Mature Height & Width: 50-70 Height. Maples require little care and pruning once established. Fertilize young trees in spring with a tree plant food. When grown as a lawn tree, create a mulch ring around the tree to keep the soil evenly moist and protect the tree trunk from damage due to lawn mowers and string trimmers. Once established, older trees are drought tolerant. saccharinum) are tolerant of seasonal flooding. Sugar maples are not tolerant of salt spray, heat and air pollution. Avoid alkaline soils since they can cause nutrient deficiencies. Purchase trees from a local nursery and plant from spring to early fall in well-drained, moist, fertile soil in a full to part sun location. Maples are generally hardy throughout New England, but some hybrids may vary in their hardiness. ![]() saccharum) is famous for yielding sweet sap used to make maple syrup. Throughout New England, and especially where I live in Vermont, the sugar maple ( A. griseum) has attractive exfoliating bark that gives the tree winter interest as well. But maples aren’t just about the fall foliage. Here I’ll talk about the large maples that make great shade trees, add country charm to a residence and produce the highly desired fall foliage show. I covered the smaller growing Japanese maple in a separate section. People travel from around the world to see the fall foliage colors of New England and the maple is one of the primary trees making this display so amazing. Native, fall color, drought tolerance, deer resistant Grown mostly for its stature and vibrant, yellow, orange, and red fall leaf colors So that being said I would recommend this vehicle to large families but I would also make sure to check every issue you wouldn’t think to check in a new vehicle like door locks and tow hook ups. from 72712 Check availability Show details View all 23 photos Used 2011. Were your new and used vehicle dealership serving Fayetteville, Centerton, and Rogers. 12,980 1,010 price drop Fair Deal Free CARFAX 1-Owner Report Napletons St. Last issue a vehicle this big should be all wheel drive it should handle better in adverse weather. Shop Nissan NV Passenger NV3500 HD Passenger Vans in Bentonville, AR for sale at . Search Nissan vehicles for sale in Bentonville, AR at McLarty Daniel Nissan. Then the motor to the back heater is going out already and that’s a $800 fix it’s only 4 years old that shouldn’t be going out already. Next my tow electrical hook ups every time we try to hook up anything to tow it kills my battery to the point we have had to buy a new but magically no one can find the issue. Were your premier Chevrolet, Buick, and GMC dealership serving Rogers. Confirm Availability Video Walkaround Test Drive Delivery Online Paperwork Used 2021 Nissan NV SV 59,854 miles 47,781 See estimated payment Excellence Auto Direct KBB.com Dealer Rating 4. ![]() Now it’s a $700 fix that I have to pay out of pocket. Search new Nissan Armada vehicles for sale in Bentonville, AR at McLarty Daniel. It is a spacious van, which comes with numerous seating. This versatile crossover also comes with a refined interior with ample storage options. Conquer streets with the new Nissan NV Passenger in Bentonville, AR. It is a spacious van, which comes with numerous seating configurations. ![]() So my still issues after 4 years is the sliding door lock has a defect and has since we bought it but since the dealership couldn’t get it to stick like it did for us they wouldn’t fix it. Come to our showroom and look at the all-new Nissan NV Passenger on our Bentonville, AR lot. Come to our showroom and look at the all-new Nissan NV Passenger on our Bentonville, AR lot. We bought it brand new and in the first 3 months it was in the shop 6 times. ![]() Learn more about features, trims, colors, specs, and more. I really like the NV it’s great for a big family and traveling. Explore the interior and exterior features of the 2019 NV Passenger. ![]() Donny Osmond reached number one with " Morning Side of the Mountain", a duet with his sister Marie, and later returned to the top spot alongside his brothers in the group The Osmonds. The song was an unexpected reunion for Simon & Garfunkel, who had not recorded together since 1970. Art Garfunkel topped the chart with his solo single " I Only Have Eyes for You" as well as with " My Little Town" with erstwhile singing partner Paul Simon. Two other singers achieved two chart-toppers in different guises. Campbell and Denver were among four acts to achieve two Easy Listening number ones in 1975, along with Captain & Tennille and Helen Reddy. At the time, the rise of the smooth style dubbed countrypolitan meant that there was considerable crossover between the country and easy listening radio formats. īoth " Rhinestone Cowboy" by Glen Campbell and " I'm Sorry" by John Denver were triple chart-toppers, as in addition to topping both the Easy Listening chart and the Hot 100, both songs also topped the Hot Country Songs listing. ![]() Although it only topped the Easy Listening chart for a single week, Captain & Tennille's " Love Will Keep Us Together" was the biggest-selling single of 1975. Easy Listening chart-toppers by Manilow, Netwon-John and The Carpenters also topped Billboard 's all-genre singles chart, the Hot 100, reflecting the fact that at the time mellower styles were popular across a range of demographics and on top 40 radio as well as the easy listening format. Please" and " Something Better to Do" each spent three consecutive weeks at number one, the only tracks to do so during the year. She also recorded the longest unbroken run atop the chart, as her songs " Please Mr. Newton-John had the highest total number of weeks at number one of any act, spending seven weeks in the top spot. Manilow was one of three acts to achieve three Easy Listening chart-toppers in 1975, along with Olivia Newton-John and The Carpenters. Starr thus became the second former member of The Beatles to have an Easy Listening number one since the group's break-up, following Paul McCartney's success with " My Love" in 1973. The first number one of the year was " Mandy" by Barry Manilow, which retained its position from the last chart of 1974, but held the top spot for only one week in 1975 before being replaced by Ringo Starr's recording of the 1950s song " Only You". ![]() In 1975, 42 songs topped the chart, then published under the title Easy Listening, based on playlists submitted by easy listening radio stations and sales reports submitted by stores. Barry Manilow had three number ones in 1975.Īdult Contemporary is a chart published by Billboard ranking the top-performing songs in the United States in the adult contemporary music (AC) market. Results showed that the subscale reliability for Analytic-Autonomizing dimension was weak in the Chinese population, and the factor analysis exposed stronger results for the American sample than for the Chinese group. It was found that, while the SDI may have value as an educational tool, its utility as a cross-cultural research instrument is questionable, largely due to the ipsative nature of the scales. Validity was examined within each culture separately, and then results were compared between the two cultures. 127 Chinese respondents from Hong Kong were the sample from a collectivistic culture. 564 American participants represented the normative sample within an individualistic culture. The present study sought to validate the SDI as a research instrument for individuals within an individualistic and a collectivistic culture. Users of SDI Facilitation Software will find this section helpful in answering most of your technical and efficiency questions.The Strength Deployment Inventory (SDI) purports to be a universal instrument for measuring three primary motivational values: Altrustic-Nurturing, Assertive-Directing, and Analytic-Autonomizing. Keep up-to-date with the latest news from Personal Strengths UK Ltd. Included here are a selection of articles written for – or about – Relationship Awareness and the SDI These are great ways to tap into our expertise in order to build on your own skills and confidence. These are fee-based services available to Qualified SDI Facilitators who want to get up to speed with Relationship Awareness® training and the SDI. ![]()
![]() ![]() A Good Laboratory Practice-compliant tissue cross-reactivity study of MEDI-547 conducted on a full panel of normal human tissues from 3 donors demonstrated rare, weak staining of the epithelium of tonsilar crypts and esophageal mucosa, and occasional, weak cytoplasmic staining of placental trophoblastic epithelium. Ī primary concern for any new targeted cancer therapy is the range and sensitivity of potentially susceptible tissues, both normal and malignant. Upon internalization of MEDI-547, cysteine (cys)-mcMMAF is released from 1C1 by lysosomal degradation of the antibody component, inducing cell cycle arrest at the G2 – M border, microtubule disruption, and apoptotic cell death. MEDI-547 binds human, cynomolgus monkey, mouse, and rat EphA2 with similar binding affinities via the highly conserved extracellular domain (MedImmune, LLC, data on file). Auristatin is a microtubule inhibitor that binds to the vinca alkaloid-binding domain, and has been shown to exhibit potent anticancer effects in preclinical and clinical studies. The antibody has no antitumor effects when unconjugated thus, it was intended to be used to deliver highly toxic chemotherapy directly to EphA2-expressing cancer cells. MEDI-547 is an ADC composed of a human immunoglobulin (Ig) G1 monoclonal antibody directed against EphA2 (known as 1C1) and conjugated on cysteine residues to an auristatin derivative linker-toxin maleimidocaproyl-monomethyl auristatin phenylalanine (mcMMAF). In addition to serving as a direct target, EphA2 could be used as a cancer-related protein for antibody-targeting therapy, particularly antibody-drug conjugate (ADC)-based therapies, in which chemical toxins or radioligands are covalently added to the antibody structure. ![]() Collectively, these findings suggest that EphA2 may be an ideal tumor target for cancer therapy. EphA2 overexpression in several types of cancers has been correlated with poor patient outcome. While EphA2 is expressed at relatively low levels in normal adult tissues, it is overexpressed in a number of carcinomas, including ovarian, endometrial, and cervical cancers melanoma and gliomas. These events occur through the interaction of the Eph receptors with their ligands, the ephrins, that are anchored to the membrane of adjacent cells. Conclusions The safety profile of MEDI-547 does not support further clinical investigation in patients with advanced solid tumors.Įphrin type-A receptor 2 (EphA2), a member of the Eph family of receptor tyrosine kinases, is involved in developmental cell-to-cell interactions and cell migration processes, including angiogenesis and neural crest cell migration. No accumulation of MEDI-547 was observed at 0.08 mg/kg upon administration of a second dose 3 weeks following dose 1. Serum MEDI-547 concentrations decreased rapidly, ~70% by 3 days post-dose. Minimal or no dissociation of toxin from 1C1 conjugate occurred in the blood. Best response included progressive disease ( n = 5 83.3%) and stable disease ( n = 1 16.7%). Three patients (50%) experienced treatment-related serious AEs, including conjunctival hemorrhage, pain (led to study drug discontinuation), liver disorder, and hemorrhage. The most frequently reported treatment-related adverse events (AEs) were increased liver enzymes, decreased hemoglobin, decreased appetite, and epistaxis. Therefore, lower doses were not explored and an MTD could not be selected. The study was stopped before cohort 2 enrollment due to treatment-related bleeding and coagulation events (hemorrhage-related, n = 3 epistaxis, n = 2). Results Six patients received 0.08 mg/kg all discontinued treatment. Methods In this phase 1, open-label study with planned dose-escalation and dose-expansion cohorts, patients received a 1-h intravenous infusion of MEDI-547 (0.08 mg/kg) every 3 weeks. We aimed to evaluate the safety profile, maximum tolerated dose (MTD), pharmacokinetics, and antitumor activity of MEDI-547, an antibody drug conjugate composed of the cytotoxic drug auristatin (toxin) linked to a human anti-EphA2 monoclonal antibody (1C1), in patients with solid tumors relapsed/refractory to standard therapy. Background Targeting the cell-surface receptor EphA2, which is highly expressed in some solid tumors, is a novel approach for cancer therapy. Nonetheless, from a fantastic life in plastic to (maybe) being part of a fantastic super squad, Robbie’s cinematic takeover continues. Can you image the Invisible Woman saying “puddin'”? But if anyone could make history by doing so, it’d be Robbie (that’s if rumors of her MCU moment are true). Ryan Reynolds played Green Lantern and Deadpool, while Ben Affleck took on Daredevil and then Batman (not at the same time, of course). Even director James Gunn made the leap from Marvel to DC.Īn actor being a part of two cinematic universes simultaneously is relatively unheard of. Digital artist m.design34 recently took to Instagram to share an impressive piece of concept art featuring Margot Robbie in the role of Sue Storm/Invisible Woman in Fantastic Four. It’s not uncommon for Hollywood folks to hop from one cinematic universe to the next. FANTASTIC FOUR: A Top Contender For Invisible Woman May Have Emerged And They Could Be Cast By Next Week We're getting closer to learning who will star in Marvel Studios' Fantastic Four. Jessica Alba: Invisible Woman, Susan Storm. ![]() With Robbie potentially joining the MCU, could this be her farewell to DC? Remember: Robbie is DC’s current Harley Quinn and has played the beloved character in three films. Fantastic Four: Rise of the Silver Surfer (2007) Jessica Alba as Invisible Woman, Susan Storm. ![]() Robbie follows Jessica Alba and Kate Mara, who played the role of Sue Storm in the past films (personally, the OG Alba is my fave). Though, the company was generous enough to announce the movie’s release date (November 8, 2024) and director (Matt Shakman) during last year’s D23 Expo. Again, the casting leak is but a rumor (for now) as Marvel remains pretty tight-lipped about the Fantastic Four, including who’s in it. ![]() The movie is about police officers trying to cover up their wrongdoings and audiences got to see a serious side of Chris. The year 2008 saw Chris Evans' part of the movie Street Kings (2008), playing the character Detective Paul Diskant. The Nanny Diaries (2007), where Evans played Harvard Hottie, showed his sensitive. Chris received positive reviews for his performance. The year 2007 also proved to be one successful year for Chris, as he had two movies released around the world that same year, starting with the second installment of the Marvel franchise Fantastic Four. In that year itself, Chris was noticed by critics and made it into magazine and Internet countdowns, scoring himself a third position of the hot body countdown from Gay.com and #18 on E! Television's 2006 101 Sexiest Celebrity Bodies. Although the film was wildly uneven and disappointing, Evans nearly stole the show with his energetic, unfettered performance. Evans then prepared himself for super stardom when he signed on to play Johnny Storm in Fantastic Four (2005), 20th Century Fox's long-awaited adaptation of the Marvel comic. Despite an unassuming performance from Evans and Kim Basinger as the damsel in distress, Cellular (2004) failed to break any box office records or please a wide majority of critics. Then, Evans broke through to the Big Time, grabbing the lead in the kidnapping thriller, Cellular (2004), a suspenseful B movie with a cheesy gimmick - a random wrong number on his cell phone forces him into a high-stakes race to save an unknown woman's life. After filming a couple of television pilots he was confident would be successful - Just Married (2003) and Eastwick (2002) - he appeared in another listless teen comedy, The Perfect Score (2004), playing an average, ho-hum student who takes part in a plot to steal the SAT test. He then appeared in his first major feature, Not Another Teen Movie (2001), a spoof on teen comedies wherein he played a jock who makes a bet that he can turn an unpopular and unkempt girl ( Chyler Leigh) into prom queen. After small roles in Cherry Falls (2000) and The Newcomers (2000) - two unknown low-budget features - Evans appeared in Boston Public (2000) (Fox, 2000-2004) as a murder suspect. Richard Kimble - incognito as a liquor store owner - refuses to sell him and his friends alcohol. In the episode "Guilt", Evans played the son of a small-town sheriff who tries to exact revenge after Dr. Evans made one of his first appearances on The Fugitive (2000) (CBS, 2000-2001), a remake of the 1960s series and feature film starring Harrison Ford. The screen - not the stage - then became his focus Evans soon began auditioning for feature films and television series. On the advice of friends, he landed an internship at a casting office and befriended a couple of the agents he regularly communicated with - one of whom later took him on as a client. ![]() After more plays and regional theatre, he moved to New York and attended the Lee Strasberg Theatre Institute. While at Lincoln-Sudbury Regional High School, his drama teacher cited his performance as "Leontes" in "The Winter's Tale" as exemplary of his skill. Bitten by the acting bug in the first grade because his older sister, Carly, started performing, Evans followed suit and began appearing in school plays. The family moved to suburban Sudbury when he was 11 years-old. He has an older sister, Carly Evans, and two younger siblings, a brother named Scott Evans, who is also an actor, and a sister named Shana Evans. Chris's father is of half German and half Welsh/English/Scottish ancestry, while Chris's mother is of half Italian and half Irish descent. He was born in Boston, Massachusetts, the son of Lisa (Capuano), who worked at the Concord Youth Theatre, and G. ![]() Evans began his acting career in typical fashion: performing in school productions and community theatre. Christopher Robert Evans is an American actor, film producer, and director. |
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